Traditional master's programs in bioengineering, biology, and related disciplines typically focus on scientific fundamentals and early-stage research, but generally lack training in key topic areas such as leadership, clinical exposure, intellectual property, and FDA regulations, which are necessary tools for bringing new medical innovations to the marketplace. This presentation will focus on the lessons learned during the development and early implementation of a unique master's program focused on translational medicine: the process of "translating" new medical innovations into novel clinical devices or therapies. Specifically, this presentation will address issues related to the specialized curriculum required for fostering medical innovation and entrepreneurship, including coursework that combines technical-, clinical-, and business-related classes with team-based projects focused specifically on biomedical translation. The presentation will also address the benefits and pitfalls of operating a multi-campus program, and the various issues involved in building a new program from the ground up.